Saving stuff to the cloud shouldn't have any effect on the file itself, it's just a collection of bits. However, accessing a document from the cloud may present some issues.
When you save to the cloud you are putting the file in a database record rather than saving the file to a location in the filing system. Directly accessing the file from the cloud may cause problems, especially if you have related resources such as images.
Have you downloaded the file to a local drive before you tried accessing it?
If not, try that first.
If so, what message are you getting and what is producing the message? (I.e. What says you can't open the file?)
Also, what OS are you using on your home system and notebook and what cloud service are you using?
We'll need a bit more information than "I can't open a file" to fix this.